Preclinical Services

Pronexus preclinical core expertise covers in vivo techniques for monitoring chemical signaling in brain and other organs using microdialysis, evaluation of candidate drugs on experimental models of human diseases, PK/PD studies and testing drug delivery systems. Applications of microdialysis in drug discovery require a unique combination of knowledge in neuroanatomy and pharmacology of major neurotransmitter systems and related bioanalytical techniques.

Microdialysis protocols on anesthetized or awake rats and mice

Preparing Microdialysis protocols for "Proof-of-principle" studies, monitoring neurotransmitters, metabolites and other surrogate markers. The microdialysis experiments can be carried out with simultaneous recordings of locomotor activity, alternatively other behavioral tests compatible with microdialysis sampling.

Pharmacokinetics and drug brain delivery

Design of protocols for Single, Dual- or Triple probe microdialysis - PK profiles of drug concentrations in body compartments including microdialysates (ISF), blood, CSF and brain tissue. Targeted drug delivery through the BBB.