Bioanalytical Services

Pronexus expertise covers liquid chromatography techniques for high-sensitive analysis of endogenous molecules including classic neurotransmitters, their precursors and metabolites, neuromodulators and other neurochemically active small molecules.  

UHPLC-MS/MS systems for small molecules

Techniques applying ultra high performance liquid chromatography with tandem mass spectrometry allow detection of endogenous molecules and their metabolites, as well as, the test compounds and drugs used as positive controls in biological samples including microdialysates, cell lysates, CSF, plasma and brain tissue extracts.

HPLC with electrochemical or fluorescence detection

Techniques optimized for analysis of neurotransmitters, neuromodulators and related molecules in the microdialysates: Serotonin, norepinephrine, dopamine and their metabolites, acetylcholine, GABA, aspartate and glutamate, glycine, physiological amino acids, histamine, adenosine and other purines, cAMP, cGMP, kynurenic acid and other metabolites of the kynurenine pathway, radical oxygen species (ROS), NO^2-/NO^3- anions.